Anti-POLK / DNA Polymerase Kappa Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | Q9UBT6 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 98809 Da |
Dilution | IF (1:50 - 1:200), IHC-P (1:100), WB (1:500 - 1:2000) |
Gene ID | 51426 |
---|---|
Alias Symbol | POLK |
Other Names | POLK, DINP, DNA polymerase kappa, DINB1, DINB protein |
Target/Specificity | Human POLK / DNA Polymerase Kappa |
Reconstitution & Storage | Affinity purified |
Precautions | Anti-POLK / DNA Polymerase Kappa Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | POLK |
---|---|
Synonyms | DINB1 |
Function | DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. |
Cellular Location | Nucleus. Note=Detected throughout the nucleus and at replication foci (PubMed:12414988). Recruited to DNA damage sites in response to ultraviolet irradiation: N6-methyladenosine (m6A)- containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is required to recruit POLK (PubMed:28297716) |
Tissue Location | Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes |
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