Anti-ACOT8 Antibody (aa131-180)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | O14734 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 35914 Da |
Dilution | ELISA, IF, IHC-P (1:50), WB |
Gene ID | 10005 |
---|---|
Alias Symbol | ACOT8 |
Other Names | ACOT8, Acyl-CoA thioesterase 8, Acyl-coenzyme A thioesterase 8, ACTEIII, HNAACTE, HACTE-III, HACTEIII, PTE-1, Thioesterase II, Palmitoyl-CoA hydrolase, PTE1, Choloyl-CoA hydrolase, HTE, PTE-2, PTE2, Thioesterase III |
Target/Specificity | ACOT8 Antibody detects endogenous levels of total ACOT8 protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-ACOT8 Antibody (aa131-180) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ACOT8 |
---|---|
Synonyms | ACTEIII, PTE1 {ECO:0000303|PubMed:100925 |
Function | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:9299485, PubMed:9153233, PubMed:15194431). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9299485, PubMed:9153233). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431). |
Cellular Location | Peroxisome matrix. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded |
Tissue Location | Detected in a T-cell line (at protein level). Ubiquitous (PubMed:9153233, PubMed:9299485) |
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