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Anti-ACOT8 Antibody (aa131-180)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O14734
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 35914 Da
Dilution ELISA, IF, IHC-P (1:50), WB
Additional Information
Gene ID 10005
Alias Symbol ACOT8
Other Names ACOT8, Acyl-CoA thioesterase 8, Acyl-coenzyme A thioesterase 8, ACTEIII, HNAACTE, HACTE-III, HACTEIII, PTE-1, Thioesterase II, Palmitoyl-CoA hydrolase, PTE1, Choloyl-CoA hydrolase, HTE, PTE-2, PTE2, Thioesterase III
Target/Specificity ACOT8 Antibody detects endogenous levels of total ACOT8 protein.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-ACOT8 Antibody (aa131-180) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACOT8
Synonyms ACTEIII, PTE1 {ECO:0000303|PubMed:100925
Function Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:9299485, PubMed:9153233, PubMed:15194431). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9299485, PubMed:9153233). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).
Cellular Location Peroxisome matrix. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded
Tissue Location Detected in a T-cell line (at protein level). Ubiquitous (PubMed:9153233, PubMed:9299485)
Research Areas
Citations (0)
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Discontinued
Cat# ALS18352
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