|Application ||WB, IHC-P, IF, E|
|Calculated MW||35914 Da|
|Dilution||ELISA, IF, IHC-P (1:50), WB|
|Other Names||ACOT8, Acyl-CoA thioesterase 8, Acyl-coenzyme A thioesterase 8, ACTEIII, HNAACTE, HACTE-III, HACTEIII, PTE-1, Thioesterase II, Palmitoyl-CoA hydrolase, PTE1, Choloyl-CoA hydrolase, HTE, PTE-2, PTE2, Thioesterase III|
|Target/Specificity||ACOT8 Antibody detects endogenous levels of total ACOT8 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-ACOT8 Antibody (aa131-180) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACTEIII, PTE1, PTE2|
|Function||Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.|
|Tissue Location||Detected in a T-cell line (at protein level). Ubiquitous.|
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