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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-PTGR1 / LTB4DH Antibody (aa75-124)
Anti-PTGR1 / LTB4DH Antibody (aa75-124)
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q14914 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 35870 Da |
| Dilution | ELISA, IHC-P (1:50), WB |
| Gene ID | 22949 |
|---|---|
| Alias Symbol | PTGR1 |
| Other Names | PTGR1, PGR1, ZADH3, PRG-1, LTB4DH, Prostaglandin reductase 1 |
| Target/Specificity | PTGR1 Antibody detects endogenous levels of total PTGR1 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-PTGR1 / LTB4DH Antibody (aa75-124) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTGR1 |
|---|---|
| Synonyms | LTB4DH |
| Function | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15- oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15- oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:25619643) (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q29073}. |
| Tissue Location | High expression in the kidney, liver, and intestine but not in leukocytes. |
Research Areas
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