|Application ||WB, IHC-P, E|
|Calculated MW||58113 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||PSAP, Cerebroside sulfate activator, GLBA, Proactivator polypeptide, Prosaposin, SAP1|
|Target/Specificity||PSAP Antibody detects endogenous levels of total PSAP protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-PSAP / Prosaposin Antibody (aa307-356) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 18.104.22.168) and galactosylceramide by beta-galactosylceramidase (EC 22.214.171.124). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 126.96.36.199). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|
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