|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||111631 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||OPA1, KIAA0567, MGM1, LargeG, NPG, NTG, Optic atrophy protein 1|
|Target/Specificity||OPA1 antibody detects endogenous levels of OPA1.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-OPA1 Antibody (aa901-950) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. May also play a role in mitochondrial genome maintenance.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space|
|Tissue Location||Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues.|
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