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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-CASP5 / Caspase 5 Antibody (aa102-151)
Anti-CASP5 / Caspase 5 Antibody (aa102-151)
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P51878 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 49736 Da |
| Dilution | ELISA, IHC-P (1:50), WB |
| Gene ID | 838 |
|---|---|
| Alias Symbol | CASP5 |
| Other Names | CASP5, CASP-5, Caspase 5, Caspase-5, ICE(rel)III, ICEREL-III, ICE(rel)-III, Ich-3, Protease TY, ICH3, Protease ICH-3, TY protease |
| Target/Specificity | Caspase 5 (p20,Cleaved-Asp121) Antibody detects endogenous levels of fragment of activated Caspase 5 resulting from cleavage adjacent to Asp121. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-CASP5 / Caspase 5 Antibody (aa102-151) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CASP5 {ECO:0000303|PubMed:16893518, ECO:0000312|HGNC:HGNC:1506} |
|---|---|
| Function | Thiol protease that acts as a mediator of programmed cell death (PubMed:29898893, PubMed:28314590). Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin- D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:29898893). Also mediates cleavage and maturation of IL18 (PubMed:37993714). Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 (PubMed:37993714). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). |
| Tissue Location | Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 555.50
Cat# ALS18376
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