|Application ||IHC-P, ICC, IP, Func, Flo|
|Calculated MW||47878 Da|
|Dilution||Flo, Func, ICC, IHC-P (10 µg/ml), IP|
|Other Names||TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9|
|Target/Specificity||Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.|
|Reconstitution & Storage||Protein G purified|
|Precautions||Anti-TNFRSF10B / Killer / DR5 Antibody (clone HS201) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DR5, KILLER, TRAILR2, TRICK2, ZTNFR9|
|Function||Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain|
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