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Anti-TNFRSF10B / Killer / DR5 Antibody (clone HS201)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC, IP, Func, Flo
Primary Accession O14763
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names HS201
Calculated MW 47878 Da
Dilution Flo, Func, ICC, IHC-P (10 µg/ml), IP
Additional Information
Gene ID 8795
Alias Symbol TNFRSF10B
Other Names TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9
Target/Specificity Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.
Reconstitution & Storage Protein G purified
PrecautionsAnti-TNFRSF10B / Killer / DR5 Antibody (clone HS201) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain
Research Areas
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$ 395.00
Cat# ALS18383
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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