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Anti-EAR2 / NR2F6 Antibody (aa210-400)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10588
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 42979 Da
Dilution IHC-P (5 µg/ml), WB
Additional Information
Gene ID 2063
Alias Symbol NR2F6
Other Names NR2F6, Erba related 2, ERBAL2, EAR-2, EAR2, ERBA-related gene-2, V-erbA-related protein 2
Target/Specificity Human EAR2 / NR2F6
Reconstitution & Storage Purified
PrecautionsAnti-EAR2 / NR2F6 Antibody (aa210-400) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR2F6
Synonyms EAR2, ERBAL2
Function Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:18701084}
Tissue Location Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.
Research Areas
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$ 395.00
Cat# ALS18395
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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