|Application ||WB, IHC-P|
|Calculated MW||28819 Da|
|Dilution||IHC-P (5 µg/ml), WB|
|Other Names||SPIB, SPI-B, Spi-b transcription factor, Transcription factor Spi-B|
|Reconstitution & Storage||Purified|
|Precautions||Anti-SPIB Antibody (aa50-260) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.|
|Cellular Location||Isoform 1: Nucleus.|
|Tissue Location||Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver|
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