|Application ||WB, IHC-P, IF, ICC, E, Flo|
|Predicted||Human, Rat, Monkey|
|Calculated MW||49244 Da|
|Dilution||ELISA (1:10000), Flo (1:200 - 1:400), ICC (1:200 - 1:1000), IF (1:1000), IHC-P (1:100), WB (1:500 - 1:2000)|
|Other Names||PDK1, PDHK, PDH kinase 1, PDHK1|
|Reconstitution & Storage||Ascites|
|Precautions||Anti-PDK1 Antibody (clone 4A11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas|
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