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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-PDK1 Antibody (clone 4A11)   

Anti-PDK1 Antibody (clone 4A11)

Mouse Anti Human Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E, Flo
Primary Accession Q15118
Predicted Human, Rat, Monkey
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 4A11
Calculated MW 49244 Da
Dilution ELISA (1:10000), Flo (1:200 - 1:400), ICC (1:200 - 1:1000), IF (1:1000), IHC-P (1:100), WB (1:500 - 1:2000)
Additional Information
Gene ID 5163
Alias Symbol PDK1
Other Names PDK1, PDHK, PDH kinase 1, PDHK1
Target/Specificity Human PDK1
Reconstitution & Storage Ascites
PrecautionsAnti-PDK1 Antibody (clone 4A11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDK1
Synonyms PDHK1
Function Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Cellular Location Mitochondrion matrix
Tissue Location Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas
Research Areas
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$ 395.00
Cat# ALS18408
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