|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Monkey, Bovine|
|Calculated MW||15046 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||PFN2, D3S1319E, PFL, Profilin II, Profilin-2, Profilin 2|
|Target/Specificity||Recognizes endogenous levels of Profilin 2 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-PFN2 / Profilin 2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver|
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