Anti-RCHY1 / PIRH2 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, ICC |
---|---|
Primary Accession | Q96PM5 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 30110 Da |
Dilution | ICC (1:100 - 1:1000), IF (1:100 - 1:1000), IHC-P (5 µg/ml), WB (1:500 - 1:3000) |
Gene ID | 25898 |
---|---|
Alias Symbol | RCHY1 |
Other Names | RCHY1, ARNIP, CHIMP, HARNIP, HPirh2, PIRH2E, PIRH2, PIRH2F, PRO1996, RING finger protein 199, Zinc finger protein 363, ZNF363, p53-induced RING-H2 protein, RNF199 |
Target/Specificity | Human RCHY1 / PIRH2 |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-RCHY1 / PIRH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RCHY1 |
---|---|
Function | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:19483087, PubMed:19043414, PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19483087, PubMed:19043414). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). |
Cellular Location | Nucleus. Nucleus speckle. Cytoplasm |
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