|Application ||WB, IHC-P|
|Calculated MW||54864 Da|
|Dilution||IHC-P (1:50), WB (1:2000)|
|Other Names||MDM4, Mdm2-like p53-binding protein, MDMX, HDMX, MRP1, p53-binding protein Mdm4, Protein Mdm4, Double minute 4 protein, MDM4-related protein 1, Protein Mdmx|
|Target/Specificity||Human MDM4 / MDMX|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-MDM4 / MDMX Antibody (clone 4G3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.|
|Tissue Location||Expressed in all tissues tested with high levels in thymus|
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