|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||62581 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||SLC22A2, HOCT2, OCT2, Organic cation transporter 2|
|Target/Specificity||Recognizes endogenous levels of SLC22A2 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SLC22A2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma.|
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