|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||77101 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||KCNQ4, DFNA2A, DFNA2, KV7.4, KQT-like 4, Potassium channel KQT-like 4|
|Target/Specificity||Recognizes endogenous levels of Kv7.4 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-KCNQ4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.|
|Cellular Location||Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells.|
|Tissue Location||Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.