|Application ||WB, IHC-P, IP|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Bovine, Dog|
|Calculated MW||108296 Da|
|Dilution||IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000)|
|Other Names||MAP3K13, Leucine zipper-bearing kinase, LZK, Mixed lineage kinase, MLK, MEKK13|
|Target/Specificity||Recognizes endogenous levels of LZK protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-MAP3K13 / LZK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas|
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