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Anti-ABCB10 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | Q9NRK6 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 79148 Da |
| Dilution | ICC (1:100 - 1:500), IF (1:100 - 1:500), IHC-P (1:100), WB (1:500 - 1:1000) |
| Gene ID | 23456 |
|---|---|
| Alias Symbol | ABCB10 |
| Other Names | ABCB10, ABC-me, ABC transporter 10 protein, M-ABC2, EST20237, MTABC2 |
| Target/Specificity | Recognizes endogenous levels of ABCB10 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-ABCB10 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCB10 (HGNC:41) |
|---|---|
| Function | Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:33253225). May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:33253225). Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:28808058, PubMed:22085049). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685). |
| Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9JI39}; Multi-pass membrane protein |
| Tissue Location | Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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