|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||135256 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Target/Specificity||Recognizes endogenous levels of RAPH1 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-RAPH1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ALS2CR18, ALS2CR9, KIAA1681, LPD, PREL2,|
|Function||Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Note=Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin|
|Tissue Location||Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells.|
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