Anti-RAPH1 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q70E73 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 135256 Da |
Dilution | IHC-P (1:100), WB (1:500 - 1:1000) |
Gene ID | 65059 |
---|---|
Alias Symbol | RAPH1 |
Other Names | RAPH1 |
Target/Specificity | Recognizes endogenous levels of RAPH1 protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-RAPH1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RAPH1 |
---|---|
Synonyms | ALS2CR18, ALS2CR9, KIAA1681, LPD, PREL2, |
Function | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Note=Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin |
Tissue Location | Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells. |
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