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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-AKAP5 / AKAP79 Antibody (N-Terminus)
Anti-AKAP5 / AKAP79 Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | P24588 |
| Predicted | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47088 Da |
| Dilution | IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000) |
| Gene ID | 9495 |
|---|---|
| Alias Symbol | AKAP5 |
| Other Names | AKAP5, A-kinase anchor protein 79 kDa, A-kinase anchor protein, 79kDa, A-kinase anchor protein 79, A-kinase anchor protein 5, AKAP-5, AKAP75, AKAP 79, AKAP79, H21 |
| Target/Specificity | Recognizes endogenous levels of AKAP5 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-AKAP5 / AKAP79 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AKAP5 |
|---|---|
| Synonyms | AKAP79 |
| Function | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2- adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). |
| Cellular Location | Postsynaptic recycling endosome membrane; Lipid- anchor. Note=Associates with lipid rafts |
| Tissue Location | Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary |
Research Areas
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Application Protocols
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