|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||212455 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||PLXNA4, KIAA1550, PLXNA4A, Plexin A4, A, Plexin-A4, PLXNA4B, Plexin A4, Plexin A4, B, FAYV2820, PLEXA4, PRO34003|
|Target/Specificity||Recognizes endogenous levels of Plexin A4 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-PLXNA4 / Plexin A4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1550, PLXNA4A, PLXNA4B|
|Function||Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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