|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Bovine|
|Calculated MW||8569 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||APLN, AGTRL1 ligand, Apelin, APEL, Preproapelin, APJ endogenous ligand, XNPEP2|
|Target/Specificity||Recognizes endogenous levels of Apelin protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-Apelin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.|
|Tissue Location||Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk|
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