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Anti-FGF1 / Acidic FGF Antibody (clone 5F12C10)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05230
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b,k
Clone Names 5F12C10
Calculated MW 17460 Da
Dilution ELISA (0.05 - 0.2 µg/ml), IHC-P (20 µg/ml), WB (0.5 - 2 µg/ml)
Additional Information
Gene ID 2246
Alias Symbol FGF1
Other Names FGF1, AFGF, Endothelial cell growth factor, Fibroblast growth factor 1, FGFA, ECGFB, HBGF-1, GLIO703, ECGF, ECGF-beta, ECGFA, FGF-1, FGF-alpha, HBGF1
Target/Specificity This product is specific to human FGF-acidic and shows no cross-reactivity with FGF basic, hFGF6, hFGF16, or hFGF17.
Reconstitution & Storage Protein A purified
PrecautionsAnti-FGF1 / Acidic FGF Antibody (clone 5F12C10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGF1
Synonyms FGFA
Function Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Cellular Location Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Tissue Location Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle
Research Areas
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$ 395.00
Cat# ALS18458
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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