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Anti-HTRA2 / OMI Antibody (aa200-250)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession O43464
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 48841 Da
Dilution Flo (1 - 3 µg/10E6 cells), IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml)
Additional Information
Gene ID 27429
Alias Symbol HTRA2
Other Names HTRA2, HtrA-like serine protease, OMI, PARK13, Protease, serine, 25, PRSS25, Serine protease 25, HtrA serine peptidase 2, Serine proteinase OMI
Target/Specificity Endogenous levels of human, mouse, and rat HtrA2. Positive Control: HeLa, HEK293, SH-SY5Y, mouse brain and rat brain.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-HTRA2 / OMI Antibody (aa200-250) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTRA2
Synonyms OMI, PRSS25
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Cellular Location Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID
Tissue Location Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid
Research Areas
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$ 395.00
Cat# ALS18460
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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