|Application ||WB, IHC-P, Flo|
|Calculated MW||73913 Da|
|Dilution||Flo (1 - 3 µg/10E6 cells), IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml)|
|Other Names||NDC80, HEC1, Kinetochore protein Hec1, Kinetochore associated 2, HEC, HsHec1, HsNDC80, KNTC2, TID3|
|Target/Specificity||Endogenous levels of human HEC1.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-HEC1 / NDC80 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HEC, HEC1, KNTC2|
|Function||Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.|
|Cellular Location||Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore|
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