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Anti-E6AP / UBE3A Antibody (N-Terminus)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession Q05086
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 100688 Da
Dilution Flo, IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml)
Additional Information
Gene ID 7337
Alias Symbol UBE3A
Other Names UBE3A, ANCR, E6-ap isoform-III, E6AP ubiquitin-protein ligase, EPVE6AP, HPVE6A, AS, CTCL tumor antigen se37-2, E6-AP, E6AP, Ubiquitin protein ligase E3A, Ubiquitin-protein ligase E3A
Target/Specificity UBE3A Antibody detects endogenous levels of human and mouse UBE3A. Positive Control: HeLa, A549, HepG2, HT29 and mouse brain tissue.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-E6AP / UBE3A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE3A
Synonyms E6AP, EPVE6AP, HPVE6A
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
Cellular Location Nucleus {ECO:0000250|UniProtKB:O08759}. Cytoplasm {ECO:0000250|UniProtKB:O08759}
Research Areas
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$ 395.00
Cat# ALS18469
(40 western blots)
Availability: 5 days
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