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Anti-GLRA1/Glycine Receptor Alpha 1 Antibody (N-Terminus)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P23415
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 52624 Da
Dilution IHC-P (10 µg/ml), WB (1 - 2 µg/ml)
Additional Information
Gene ID 2741
Alias Symbol GLRA1
Other Names GLRA1, Alpha 1 glycine Receptor, GlyR alpha 1, GLYRA1, SPD, STHE, Spasmodic, Glycine receptor alpha 1, Glycine receptor, alpha 1, HKPX1, Strychnine binding subunit
Target/Specificity Endogenous levels of mouse alpha 1 Glycine Receptor. It is predicted to react with human alpha 1 Glycine Receptor according to sequence homology. Positive Control: Mouse brain.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-GLRA1/Glycine Receptor Alpha 1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLRA1
Function Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity).
Cellular Location Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:Q64018}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q64018}. Cell junction, synapse {ECO:0000250|UniProtKB:Q64018}. Perikaryon {ECO:0000250|UniProtKB:Q64018}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q64018}. Cell membrane; Multi- pass membrane protein
Research Areas
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$ 395.00
Cat# ALS18471
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