|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Pig, Bovine, Dog|
|Calculated MW||38940 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||CREM, CREM-2, CREM 2alpha-b protein, CREM 2beta-a protein, HCREM-2, Inducible cAMP early repressor, ICER|
|Target/Specificity||Recognizes endogenous levels of ICER protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CREM / ICER Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).|
|Tissue Location||Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes|
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