Anti-SLC4A7 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q9Y6M7 |
Predicted | Human, Mouse, Rat, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 136044 Da |
Dilution | IHC-P (1:100), WB (1:500 - 1:1000) |
Gene ID | 9497 |
---|---|
Alias Symbol | SLC4A7 |
Other Names | SLC4A7, Bicarbonate transporter, BT, NBC2, NBC3, NBCN1, SBC2, NBC2B, MNBC3, SLC4A6 |
Target/Specificity | Recognizes endogenous levels of SLC4A7 protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-SLC4A7 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC4A7 |
---|---|
Synonyms | BT, NBC2, NBC2B, NBC3, NBCn1, SBC2, SLC4 |
Function | Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14736710, PubMed:14578046). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404). |
Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9R1N3}. Cell membrane; Multi-pass membrane protein. Note=Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO:0000250|UniProtKB:Q9R1N3} |
Tissue Location | Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. |
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