|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||25673 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||SRA1, SRAP, STRAA1, Pp7684, Steroid receptor coactivator, SRA|
|Target/Specificity||Recognizes endogenous levels of SRA protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SRA1 / SRA Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus|
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