|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||435170 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||FLG, ATOD2, Epidermal filaggrin, Filaggrin|
|Target/Specificity||Recognizes endogenous levels of Filaggrin protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-FLG / Filaggrin Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.|
|Cellular Location||Cytoplasmic granule. Note=In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719)|
|Tissue Location||Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417).|
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