|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Bovine|
|Calculated MW||23584 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||RAB8B, RAB-8b protein, Ras-related protein Rab-8B|
|Target/Specificity||Recognizes endogenous levels of RAB8B protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-RAB8B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis|
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