|Application ||WB, IHC-P, E|
|Calculated MW||34439 Da|
|Dilution||ELISA (1:2000 - 1:5000), IHC-P (10 µg/ml), WB (1:2000 - 1:5000)|
|Other Names||NMNAT2, C1orf15, KIAA0479, NaMN adenylyltransferase 2, NMN adenylyltransferase 2, PNAT2|
|Target/Specificity||Recognizes human NMNAT2.|
|Reconstitution & Storage||Protein G purified|
|Precautions||Anti-NMNAT2 Antibody (clone Nady-1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+).|
|Cellular Location||Cytoplasm. Golgi apparatus|
|Tissue Location||Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.|
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