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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-NMNAT2 Antibody (clone Nady-1)
Anti-NMNAT2 Antibody (clone Nady-1)
Mouse Anti Human Monoclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BZQ4 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | Nady-1 |
| Calculated MW | 34439 Da |
| Dilution | ELISA (1:2000 - 1:5000), IHC-P (10 µg/ml), WB (1:2000 - 1:5000) |
| Gene ID | 23057 |
|---|---|
| Alias Symbol | NMNAT2 |
| Other Names | NMNAT2, C1orf15, KIAA0479, NaMN adenylyltransferase 2, NMN adenylyltransferase 2, PNAT2 |
| Target/Specificity | Recognizes human NMNAT2. |
| Reconstitution & Storage | Protein G purified |
| Precautions | Anti-NMNAT2 Antibody (clone Nady-1) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NMNAT2 (HGNC:16789) |
|---|---|
| Function | Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Also acts as an activator of ADP- ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (PubMed:34314702). |
| Cellular Location | Golgi apparatus membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8BNJ3}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasm. Cell projection, axon {ECO:0000250|UniProtKB:Q8BNJ3}. Note=Delivered to axons with Golgi- derived cytoplasmic vesicles. {ECO:0000250|UniProtKB:Q8BNJ3} |
| Tissue Location | Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. |
Research Areas
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