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Anti-TNFSF18 / GITRL Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UNG2
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 22724 Da
Dilution ELISA (1:5000 - 1:10000), IHC-P (5 µg/ml), WB (1:2000 - 1:5000)
Additional Information
Gene ID 8995
Alias Symbol TNFSF18
Other Names TNFSF18, AITR ligand, AITRL, GITR ligand, GITRL, HGITRL, TL6
Target/Specificity Recognizes human GITRL. Detects a band of ~15-17kDa by Western blot. Does not cross-react with mouse GITRL.
Reconstitution & Storage Protein A purified
PrecautionsAnti-TNFSF18 / GITRL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFSF18
Synonyms AITRL, GITRL, TL6
Function Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells
Research Areas
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$ 395.00
Cat# ALS18501
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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