|Application ||WB, IHC-P, E|
|Calculated MW||22724 Da|
|Dilution||ELISA (1:5000 - 1:10000), IHC-P (5 µg/ml), WB (1:2000 - 1:5000)|
|Other Names||TNFSF18, AITR ligand, AITRL, GITR ligand, GITRL, HGITRL, TL6|
|Target/Specificity||Recognizes human GITRL. Detects a band of ~15-17kDa by Western blot. Does not cross-react with mouse GITRL.|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-TNFSF18 / GITRL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||AITRL, GITRL, TL6|
|Function||Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells|
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