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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-STK24 / MST3 Antibody
Anti-STK24 / MST3 Antibody
Rabbit Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y6E0 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 49308 Da |
| Dilution | ELISA, IHC-P (10 µg/ml), WB |
| Gene ID | 8428 |
|---|---|
| Alias Symbol | STK24 |
| Other Names | STK24, MST-3, MST3, Serine/threonine kinase 24, STE20-like kinase 3, STE20-like kinase MST3, MST3B, STE20, Sterile 20-like kinase 3 |
| Target/Specificity | Human STK24 / MST3 |
| Reconstitution & Storage | Caprylic acid and ammonium sulfate precipitation |
| Precautions | Anti-STK24 / MST3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STK24 |
|---|---|
| Synonyms | MST3, STK3 |
| Function | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. |
| Cellular Location | Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane |
| Tissue Location | Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex |
Research Areas
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Application Protocols
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