|Application ||WB, IHC-P, E|
|Calculated MW||49308 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||STK24, MST-3, MST3, Serine/threonine kinase 24, STE20-like kinase 3, STE20-like kinase MST3, MST3B, STE20, Sterile 20-like kinase 3|
|Target/Specificity||Human STK24 / MST3|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-STK24 / MST3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.|
|Cellular Location||Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane|
|Tissue Location||Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex|
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