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Anti-BRCC3 / BRCC36 Antibody (aa2-316)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46736
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 36072 Da
Dilution ELISA, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 79184
Alias Symbol BRCC3
Other Names BRCC3, C6.1A, BRCC36, BRISC complex subunit BRCC36, BRCA1-A complex subunit BRCC36, CXorf53, RP11-143H17.2
Target/Specificity Human BRCC3 / BRCC36
Reconstitution & Storage Caprylic acid and ammonium sulfate precipitation
PrecautionsAnti-BRCC3 / BRCC36 Antibody (aa2-316) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BRCC3
Synonyms BRCC36, C6.1A, CXorf53
Function Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.
Cellular Location Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
Tissue Location Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors.
Research Areas
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$ 395.00
Cat# ALS18514
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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