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Anti-BLOC1S1 Antibody

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P78537
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 17263 Da
Dilution ELISA, IHC-P (7.5 µg/ml), WB
Additional Information
Gene ID 2647
Alias Symbol BLOC1S1
Other Names BLOC1S1, BLOS1, BLOC-1 subunit 1, BLOC subunit 1, GCN5-like protein 1, GCN5L1, MICoA, MTA1-interacting coactivator, Protein RT14, RT14
Target/Specificity Human BLOC1S1
Reconstitution & Storage Caprylic acid and ammonium sulfate precipitation
PrecautionsAnti-BLOC1S1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BLOC1S1
Synonyms BLOS1, GCN5L1, RT14
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).
Cellular Location Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane
Research Areas
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$ 395.00
Cat# ALS18520
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