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Anti-CETN2 / Centrin 2 Antibody (aa1-172)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41208
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 19738 Da
Dilution ELISA, IHC-P (7.5 µg/ml)
Additional Information
Gene ID 1069
Alias Symbol CETN2
Other Names CETN2, Caltractin isoform 1, Centrin-2, CALT, Caltractin, isoform 1, Centrin, EF-hand protein, 2, CEN2, Centrin 2
Target/Specificity Human CETN2 / Centrin 2
Reconstitution & Storage Caprylic acid and ammonium sulfate precipitation
PrecautionsAnti-CETN2 / Centrin 2 Antibody (aa1-172) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CETN2
Synonyms CALT, CEN2
Function Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus Note=Centrosome of S-phase, interphase and mitotic cells
Research Areas
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$ 395.00
Cat# ALS18521
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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