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Anti-KAT5 / TIP60 Antibody (aa3-512)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92993
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 58582 Da
Dilution ELISA, IHC-P (7.5 µg/ml)
Additional Information
Gene ID 10524
Alias Symbol KAT5
Other Names KAT5, 60 kDa Tat-interactive protein, CPLA(2)-interacting protein, CPLA2 interacting protein, HIV-1 Tat interactive protein, ESA1, HTATIP1, Histone acetyltransferase KAT5, K-acetyltransferase 5, Lysine acetyltransferase 5, HTATIP, K(lysine) acetyltra ...
Target/Specificity Human KAT5 / cPLA2 / TIP60.
Reconstitution & Storage Caprylic acid and ammonium sulfate precipitation
PrecautionsAnti-KAT5 / TIP60 Antibody (aa3-512) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT5
Synonyms HTATIP, TIP60
Function Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).
Cellular Location Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies
Research Areas
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$ 395.00
Cat# ALS18555
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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