|Application ||IHC-P, E|
|Calculated MW||58582 Da|
|Dilution||ELISA, IHC-P (7.5 µg/ml)|
|Other Names||KAT5, 60 kDa Tat-interactive protein, CPLA(2)-interacting protein, CPLA2 interacting protein, HIV-1 Tat interactive protein, ESA1, HTATIP1, Histone acetyltransferase KAT5, K-acetyltransferase 5, Lysine acetyltransferase 5, HTATIP, K(lysine) acetyltra ...|
|Target/Specificity||Human KAT5 / cPLA2 / TIP60.|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-KAT5 / TIP60 Antibody (aa3-512) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).|
|Cellular Location||Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies|
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