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Anti-CNDP2 Antibody (aa2-475)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q96KP4 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 52878 Da |
| Dilution | ELISA, IHC-P (7.5 µg/ml) |
| Gene ID | 55748 |
|---|---|
| Alias Symbol | CNDP2 |
| Other Names | CNDP2, CN2, CPGL, CNDP dipeptidase 2, HsT2298, PEPA, Peptidase A |
| Target/Specificity | Human CNDP2 |
| Reconstitution & Storage | Caprylic acid and ammonium sulfate precipitation |
| Precautions | Anti-CNDP2 Antibody (aa2-475) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNDP2 |
|---|---|
| Function | Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343). |
| Cellular Location | Cytoplasm |
| Tissue Location | Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568) |
Research Areas
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$ 395.00
Cat# ALS18560
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