|Application ||IHC-P, E|
|Calculated MW||52878 Da|
|Dilution||ELISA, IHC-P (7.5 µg/ml)|
|Other Names||CNDP2, CN2, CPGL, CNDP dipeptidase 2, HsT2298, PEPA, Peptidase A|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-CNDP2 Antibody (aa2-475) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).|
|Tissue Location||Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568)|
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