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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-RBX1 / ROC1 Antibody
Anti-RBX1 / ROC1 Antibody
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | P62877 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 12274 Da |
| Dilution | IF, IHC-P (1:100), WB |
| Gene ID | 9978 |
|---|---|
| Alias Symbol | RBX1 |
| Other Names | RBX1, Regulator of cullins 1, RING box protein 1, ROC1, TESTICAN, Ring-box 1, RNF75, BA554C12.1, Protein ZYP, RING finger protein 75, RING-box protein 1, ZYP protein |
| Target/Specificity | Human ROC1 / RBX1 |
| Reconstitution & Storage | Affinity purified |
| Precautions | Anti-RBX1 / ROC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBX1 (HGNC:9928) |
|---|---|
| Function | E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:11961546, PubMed:22748924). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Widely expressed. |
Research Areas
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