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Anti-IRAK3 / IRAKM / IRAK-M Antibody

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9Y616
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 67767 Da
Dilution IHC-P (1:200), WB
Additional Information
Gene ID 11213
Alias Symbol IRAK3
Other Names IRAK3, ASRT5, IRAK M, IRAK-3, IL1RAK M, IRAK-M, IRAKM
Target/Specificity Human IRAK3 / IRAKM / IRAK-M.
Reconstitution & Storage Affinity purified
PrecautionsAnti-IRAK3 / IRAKM / IRAK-M Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRAK3 {ECO:0000312|EMBL:AAH57800.1}
Function Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383).
Cellular Location Cytoplasm. Nucleus. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation. {ECO:0000250|UniProtKB:Q8K4B2}
Tissue Location Expressed in eosinophils, dendritic cells and/or monocytes (at protein level) (PubMed:29686383). Expressed predominantly in peripheral blood lymphocytes (PubMed:10383454)
Research Areas
Citations (0)
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$ 467.50
Cat# ALS18602
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