|Application ||WB, IHC-P|
|Calculated MW||113377 Da|
|Dilution||IHC-P (1:100), WB|
|Other Names||ITGA2B, BDPLT2, CD41B, GT, gp2B, Integrin alpha-IIb, ITGAB, GPIIb, HPA3, Platelet-specific antigen BAK, CD41, CD41 antigen, GPalpha IIb, GTA|
|Target/Specificity||Human ITGA2B / CD41|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-ITGA2B / CD41 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells|
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