|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||94428 Da|
|Dilution||IHC-P (1:100), WB|
|Other Names||NTRK3, ETV6-NTRK3 fusion, gp145-TrkC, Neurotrophin 3 receptor, TRKC, TrkC tyrosine kinase, NT-3 growth factor receptor, NT3 growth factor receptor, Tyrosine kinase receptor C, Pan Trk, gp145(trkC), Trk-C|
|Target/Specificity||Human NTRK3 / TRKC|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-NTRK3 / TRKC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain|
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