|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||103134 Da|
|Dilution||IHC-P (1:100), WB|
|Other Names||NRP1, BDCA4, CD304, CD304 antigen, VEGF165 receptor, VEGF165R, Neuropilin 1, Neuropilin-1, Np-1, Npn-1, NRP, NP1, Transmembrane receptor|
|Target/Specificity||Human NRP1 / Neuropilin 1|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-NRP1 / Neuropilin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules|
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