Anti-ANTXR1 / TEM8 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
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Primary Accession | Q9H6X2 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 62789 Da |
Dilution | IF, IHC-P (1:100), WB |
Gene ID | 84168 |
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Alias Symbol | ANTXR1 |
Other Names | ANTXR1, Tumor endothelial marker 8, Anthrax toxin receptor 1, TEM8 |
Target/Specificity | Human ANTXR1 / TEM8 |
Reconstitution & Storage | Affinity purified |
Precautions | Anti-ANTXR1 / TEM8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ANTXR1 {ECO:0000303|PubMed:22912819, ECO:0000312|HGNC:HGNC:21014} |
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Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single- pass type I membrane protein. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). |
Tissue Location | Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells |
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