|Application ||WB, IHC-P, IF|
|Predicted||Human, Mouse, Rat|
|Calculated MW||62789 Da|
|Dilution||IF, IHC-P (1:100), WB|
|Other Names||ANTXR1, Tumor endothelial marker 8, Anthrax toxin receptor 1, TEM8|
|Target/Specificity||Human ANTXR1 / TEM8|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-ANTXR1 / TEM8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia|
|Tissue Location||Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells|
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