Anti-CNGA3 Antibody (aa1-165)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q16281 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 78838 Da |
Dilution | IHC-P (1:100), WB |
Gene ID | 1261 |
---|---|
Alias Symbol | CNGA3 |
Other Names | CNGA3, CCNCa, CCNCalpha, CCNC1, CNG channel alpha-3, CNG3, ACHM2, Achromatopsia 2, MCNG3, CNCG3, CNG-3 |
Target/Specificity | Human CNGA3 |
Reconstitution & Storage | Affinity purified |
Precautions | Anti-CNGA3 Antibody (aa1-165) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CNGA3 |
---|---|
Synonyms | CNCG3 |
Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. |
Cellular Location | Membrane; Multi-pass membrane protein. |
Tissue Location | Prominently expressed in retina. |
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