|Application ||WB, IHC-P|
|Calculated MW||78838 Da|
|Dilution||IHC-P (1:100), WB|
|Other Names||CNGA3, CCNCa, CCNCalpha, CCNC1, CNG channel alpha-3, CNG3, ACHM2, Achromatopsia 2, MCNG3, CNCG3, CNG-3|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-CNGA3 Antibody (aa1-165) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Prominently expressed in retina.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.