|Application ||WB, E|
|Other Accession||P47942, O08553, Q90635, O02675|
|Reactivity||Human, Mouse, Rat|
|Predicted||Rat, Chicken, Bovine|
|Calculated MW||62294 Da|
|Antigen Region||463-492 aa|
|Other Names||Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, CRMP-2, N2A3, Unc-33-like phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2|
|Target/Specificity||This DRP-2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from human DRP-2.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DRP-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. Koide T, et al. J Hum Genet, 2010 Jul. PMID 20414250. Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 Apr 8. PMID 20381070. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. Chae YC, et al. Cell Signal, 2009 Dec. PMID 19666111. CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. Arimura N, et al. J Neurochem, 2009 Oct. PMID 19659462.
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