|Application ||WB, E|
|Other Accession||P47942, O08553, Q90635, O02675|
|Predicted||Bovine, Chicken, Rat|
|Calculated MW||62294 Da|
|Antigen Region||463-492 aa|
|Other Names||Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, CRMP-2, N2A3, Unc-33-like phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2|
|Target/Specificity||This DRP-2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from human DRP-2.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DRP-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes|
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Provided below are standard protocols that you may find useful for product applications.
A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. Koide T, et al. J Hum Genet, 2010 Jul. PMID 20414250. Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 Apr 8. PMID 20381070. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. Chae YC, et al. Cell Signal, 2009 Dec. PMID 19666111. CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. Arimura N, et al. J Neurochem, 2009 Oct. PMID 19659462.
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