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PRDM3 Antibody

Purified Mouse Monoclonal Antibody (Mab)

  • WB - PRDM3 Antibody AM1192A
    Western analysis of extracts from 293 cells using PRDM3 antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q03112
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names 47AT612.84.88
Calculated MW 118276 Da
Additional Information
Gene ID 2122
Other Names MDS1 and EVI1 complex locus protein EVI1, Ecotropic virus integration site 1 protein homolog, EVI-1, MECOM, EVI1
Target/Specificity This PRDM3 antibody was raised using purified recombinant GST fusion protein encoding the N-terminal part of human PRDM3.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRDM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms EVI1
Function Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Cellular Location Nucleus. Nucleus speckle.
Citations (0)

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Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Bei JX, et al. Nat Genet, 2010 Jul. PMID 20512145.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. Shimahara A, et al. J Biol Chem, 2010 May 28. PMID 20363750.
EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia. Balgobind BV, et al. Leukemia, 2010 May. PMID 20357826.

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Cat# AM1192A
(40 western blots)
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