|Application ||WB, E|
|Calculated MW||118276 Da|
|Other Names||MDS1 and EVI1 complex locus protein EVI1, Ecotropic virus integration site 1 protein homolog, EVI-1, MECOM, EVI1|
|Target/Specificity||This PRDM3 antibody was raised using purified recombinant GST fusion protein encoding the N-terminal part of human PRDM3.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRDM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.|
|Cellular Location||Nucleus. Nucleus speckle.|
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Provided below are standard protocols that you may find useful for product applications.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Bei JX, et al. Nat Genet, 2010 Jul. PMID 20512145.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. Shimahara A, et al. J Biol Chem, 2010 May 28. PMID 20363750.
EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia. Balgobind BV, et al. Leukemia, 2010 May. PMID 20357826.
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