|Application ||WB, E|
|Calculated MW||138136 Da|
|Other Names||MDS1 and EVI1 complex locus protein EVI1, Ecotropic virus integration site 1 protein homolog, EVI-1, MECOM, EVI1|
|Target/Specificity||This PRDM3 antibody was raised using purified recombinant GST fusion protein encoding the N-terminal part of human PRDM3.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRDM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.|
|Cellular Location||Nucleus. Nucleus speckle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Bei JX, et al. Nat Genet, 2010 Jul. PMID 20512145.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. Shimahara A, et al. J Biol Chem, 2010 May 28. PMID 20363750.
EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia. Balgobind BV, et al. Leukemia, 2010 May. PMID 20357826.
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