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APG8a (MAP1LC3A)-S12 AntibodyPurified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM1823a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AM1823a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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APG8a (MAP1LC3A)-S12 Antibody - Product info | |
| Application | WB
|
| Primary Accession | Q9H492 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | IgG1κ |
| Clone Names | 77CT3.8.3 |
| Calculated MW | 14272 Da |
APG8a (MAP1LC3A)-S12 Antibody - Additional info | |
| Gene ID 84557 | |
| Other Names MAP1LC3A; Microtubule-associated proteins 1A/1B light chain 3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; Microtubule-associated protein 1 light chain 3 alpha | |
| Target/Specificity This APG8a (MAP1LC3A)-S12 antibody is generated from mouses immunized with a KLH conjugated synthetic phosphopeptide selected from the S12 region of human APG8a (MAP1LC3A). | |
| Dilution WB~~1:500~1000 | |
| Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions APG8a (MAP1LC3A)-S12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
APG8a (MAP1LC3A)-S12 Antibody - Protein Information | |
| Name MAP1LC3A | |
| Function Involved in formation of autophagosomal vacuoles (autophagosomes) | |
| Cellular Location Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes | |
| Tissue Location Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes | |
APG8a (MAP1LC3A)-S12 Antibody - Related products
AM1823a: APG8a (MAP1LC3A)-S12 Antibody
AP1801a: LC3 Antibody (APG8A) (N-term)
AP1801b: LC3 Antibody (APG8A) (P45)
AP1801c: LC3 Antibody (APG8A) (I31)
AP1801d: LC3 Antibody (APG8A) (D106)
AP1801e: LC3 Antibody (APG8A) (S12)
AP1801f: LC3 Antibody (APG8A) (S3)
AP1801g: LC3 Antibody (APG8A) (T93/Y99)
AP1801h: LC3 Antibody (APG8A) (T93/Y99)
AP1801i: LC3 Antibody (Isoform B Specific)
AP1805a: Cleaved LC3A Antibody
AP3301a: Phospho-LC3C-S12 Antibody
AP3620a: Phospho-LC3A-T93 Antibody
AP3641a: Phospho-LC3A-S3 Antibody
AP3706a: Phospho-APG8a (MAP1LC3A)-Y99 Antibody
RI13150: MAP1LC3A predesign siRNA
DC04198: Human MAP1LC3A cDNA Clone
BP1801a: LC3 Antibody (APG8a) (N-term) Blocking Peptide
BP1801b: LC3 (APG8a) Antibody (P45) Blocking Peptide
BP1801c: LC3 Antibody (APG8a) (I31) Blocking Peptide
BP1801d: LC3 Antibody (APG8a) (D106) Blocking Peptide
BP1801e: APG8a (MAP1LC3A) Antibody (S12) Blocking Peptide
BP1801f: APG8a (MAP1LC3A) Antibody (S3) Blocking Peptide
BP1801g: APG8a (MAP1LC3A) Antibody (T93/Y99) Blocking Peptide
BP1801h: APG8a (MAP1LC3A) Antibody (T93/Y99) Blocking Peptide
BP1801i: APG8a (MAP1LC3A) Antibody (Isoform b specific) Blocking Peptide
BP1805a: Cleaved-LC3 Antibody (APG8a) Blocking Peptide
BP3301a: Phospho-LC3 (APG8a) - S12 Antibody Blocking Peptide
BP3620a: Phospho-APG8a (MAP1LC3A)-pT93 Antibody Blocking Peptide
BP3641a: Phospho-APG8a (MAP1LC3A)-pS3 Antibody Blocking Peptide
BP3706a: Phospho-APG8a(MAP1LC3A)-Y99 Antibody Blocking Peptide
APG8a (MAP1LC3A)-S12 Antibody - Application data
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Western blot analysis of anti-APG8a (MAP1LC3A)-S12 mab (Cat. #AM1823a) in MAP1LC3A-WT cell line lysates (35ug/lane). APG8a(arrow) was detected using the purified Mab.
APG8a (MAP1LC3A)-S12 Antibody - Research Areas
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BACKGROUND
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Gao C, et al. Nat Cell Biol, 2010 Aug. PMID 20639871. The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer. Namgoong GM, et al. J Biol Chem, 2010 Jul 30. PMID 20479004. Protein kinase C inhibits autophagy and phosphorylates LC3. Jiang H, et al. Biochem Biophys Res Commun, 2010 May 14. PMID 20398630. Processing of autophagic protein LC3 by the 20S proteasome. Gao Z, et al. Autophagy, 2010 Jan. PMID 20061800. Defective autophagy associated with LC3 puncta in epothilone-resistant cancer cells. Shen S, et al. Cell Cycle, 2010 Jan 15. PMID 20023420.
