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CD34 Antibody (Center)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM1825a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AM1825a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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CD34 Antibody (Center) - Product info | |
| Application | WB, IHC
|
| Primary Accession | P28906 |
| Other Accession | NP_001764 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | IgG1κ |
| Clone Names | 132CT29.1.5 |
| Calculated MW | 40716 Da |
CD34 Antibody (Center) - Additional info | |
| Gene ID 947 | |
| Other Names CD34; Hematopoietic progenitor cell antigen CD34; CD_antigen=CD34; Flags: Precursor | |
| Target/Specificity This CD34 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the Central region of human CD34. | |
| Dilution WB~~1:500-1000 IHC~~1:50~100 | |
| Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CD34 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CD34 Antibody (Center) - Protein Information | |
| Name CD34 | |
| Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues | |
CD34 Antibody (Center) - Related products
AM1825a: CD34 Antibody (Center)
AP10666c: CD34 Antibody (Center)
AP3600a: Phospho-CD34-pY330 Antibody
BP3600a: Phospho-CD34-pY330 Antibody Blocking Peptide
AT1434a: CD34 Antibody (monoclonal) (M01)
CD34 Antibody (Center) - Application data
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Western blot analysis of anti-CD34 Antibody (Center) (Cat. #AM1825a) in mouse NIH-3T3 cell line lysates (35ug/lane). CD34 (arrow) was detected using the purified Mab.
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Formalin-fixed and paraffin-embedded human hepatocarcinoma with CD34 Monoclonal Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
CD34 Antibody (Center) - Research Areas
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BACKGROUND
CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.
REFERENCES
Genome-wide association analysis identifies multiple loci related to resting heart rate. Eijgelsheim M, et al. Hum Mol Genet, 2010 Oct 1. PMID 20639392. The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms. Cho SY, et al. Cancer Res, 2010 Apr 15. PMID 20388788. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells. Stellos K, et al. Arterioscler Thromb Vasc Biol, 2010 Jun. PMID 20378847. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3. Artico M, et al. Eur J Histochem, 2010 Mar 11. PMID 20353905.
